4-Fluorophenylboronic acid → 2-(3-Fluoro-4-hydroxyphenyl)-4-(4-fluorophenyl)quinolin-6-ol

HRID 7247

반응식

HRID 7247 반응식
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([F:20])[CH:14]=2)[CH:3]=1.[F:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1>>[F:20][C:15]1[CH:14]=[C:13]([C:4]2[CH:3]=[C:2]([C:25]3[CH:26]=[CH:27][C:22]([F:21])=[CH:23][CH:24]=3)[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:12])[CH:10]=3)[N:5]=2)[CH:18]=[CH:17][C:16]=1[OH:19]

참가 물질

3

반응물 2

HCID 2856454-Fluorophenylboronic acidHCID 1354779434-Bromo-2-(3-fluoro-4-hydroxyphenyl)quinolin-6-ol

생성물 1

HCID 1354548282-(3-Fluoro-4-hydroxyphenyl)-4-(4-fluorophenyl)quinolin-6-ol수율 90%

실험 절차

This compound was prepared from 6b using 4-fluorophenylboronic acid according to method P. Orange powder; Yield: 90%; mp 240–243° C.; 1H-NMR (300 MHz, DMSO-d6) δ 7.05 (d, J=2.6 Hz, 1H), 7.07 (dd, J=8.9, 8.7 Hz, 1H), 7.32 (dd, J=9.0, 2.6 Hz, 1H), 7.44 (dd, J=8.9, 8.9 Hz, 2H), 7.63 (m, 2H), 7.86 (s, 1H), 7.95 (dd, J=8.4, 1.9 Hz, 1H), 7.97 (d, J=9.1 Hz, 1H), 8.08 (dd, J=13.0, 2.0 Hz, 1H), 9.96 (s, 1H), 10.21 (s, 1H); MS (ESI) m/z 348 ([M−H]−), 350 ([M+H]+); Anal. Calcd for C21H13F2NO2: C: 72.20, H: 3.75, N: 4.01. Found: C: 69.48, H: 3.81, N: 3.68.

출처 및 근거

ORD 기록
ord-2fa5700fd5364c35af981aebf453db3e
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084276B2

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