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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72474생성일: 2026년 10월 25일

4-Fluoro-3-(trifluoromethyl)phenol → 2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid

https://huagongshe.com/reaction/72474

반응식

참여 물질

역할이름HCID투입량
반응물4-Fluoro-3-(trifluoromethyl)phenolHCID 601854—
반응물Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinateHCID 86697871—
생성물2-(3-(4-Fluoro-3-(trifluoromethyl)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acidHCID 8669787598.7%

반응 단계

The title compound (D125) (108 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 4-Fluoro-3-(trifluoromethyl)phenol (60.98 mg, 0.338 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08828987B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-79e437b0e96046e6aff8e2a56f024a1e
출처 메모uspto-grants-2014_09