Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Difluorophenol → 2-(3-(2,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Difluorophenol | HCID 123051 | — |
| 반응물 | Methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate | HCID 86697871 | — |
| 생성물 | 2-(3-(2,4-Difluorophenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid | HCID 67958434 | 98.4% |
반응 단계
The title compound (D127) (95 mg) was prepared according to the experimental procedure described in Description 103A starting from methyl 2-(3-((methylsulfonyl)oxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinate (D68) (100 mg, 0.258 mmol) and 2,4-Difluorophenol (0.032 ml, 0.338 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-7632ee7e99274dd39d4f902fd9eeec21 |
| 출처 메모 | uspto-grants-2014_09 |