Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1,3-Propanediol | HCID 10442 | — |
| 반응물 | N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine | HCID 9905031 | — |
| 생성물 | N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine | HCID 21948226 | — |
반응 단계
300 mg (0.95 mmol) of N-(3-chloro-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine (see Example 1), 5.3 ml of 1,3-propanediol and 3.0 ml of dimethylformamide are stirred for 43 hours at 105°. After concentration and repeated chromatography (methylene chloride:methanol=98:2) N-(3-chloro-phenyl)-4-(2-dimethylamino-4-pyridyl)-2-pyrimidineamine is obtained; m.p. 176°-178°, FAB-MS: 326 (M+ +H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05705502 |
| 출처 데이터셋 | uspto-grants-1998_01 |
| ORD ID | ord-c3482e11c2e84dc49fa14c44b98d45d5 |
| 출처 메모 | uspto-grants-1998_01 |