Ethylamine → 2-Ethylamino-3-nitropyridine

반응식

Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([NH2:13])[CH3:12]>>[CH2:11]([NH:13][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 796132-Chloro-3-nitropyridine

생성물 1

HCID 120157272-Ethylamino-3-nitropyridine수율 106.2%

반응 조건

온도: 105 °C

실험 절차

A stirred mixture of 2-chloro-3-nitropyridine (50.0 g, 0.32 mol), ethylamine (33.5 g, 0.74 mol), and xylenes (85 mL) was heated at 105° C. in a sealed vessel for three hours. After cooling, the solvent was removed in vacuo, and water was added to the residue. The product was extracted with methylene chloride, dried (sodium sulfate), and concentrated in vacuo to give 56.8 g of the title compound as a brown oil, suitable for use in the next reaction.

후처리

temperatureAfter cooling
customthe solvent was removed in vacuo, and water
additionwas added to the residue
extractionThe product was extracted with methylene chloride
dry with materialdried (sodium sulfate)
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-fd116ade73e84ac4897a647ad04306d3
출처 데이터셋: uspto-grants-1998_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05705499

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