2-Bromothiazole → HCID 470733, 화합물
반응식
[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([C:14]#[CH:15])=[CH:13][C:8]=2[C:7](=[O:16])[N:6]([CH3:17])[C:5]2[CH:18]=[CH:19][CH:20]=[N:21][C:4]1=2)[CH3:2].Br[C:23]1[S:24][CH:25]=[CH:26][N:27]=1>>[N:21]1[C:4]2[C:5](=[N:6][C:7](=[O:16])[C:8]3[CH:13]=[CH:12][CH:11]=[N:10][C:9]=3[N:3]=2)[CH:18]=[CH:19][CH:20]=1.[CH2:1]([N:3]1[C:9]2[N:10]=[CH:11][C:12]([CH2:14][CH2:15][C:23]3[S:24][CH:25]=[CH:26][N:27]=3)=[CH:13][C:8]=2[C:7](=[O:16])[N:6]([CH3:17])[C:5]2[CH:18]=[CH:19][CH:20]=[N:21][C:4]1=2)[CH3:2]참가 물질
4
실험 절차
5,11-Dihydro-11-ethyl-5-methyl-8-(2-thiazolyl)ethynyl-(-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (0.15 g) was prepared from 5,11-dihydro-11-ethyl-8-ethynyl-5-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one and 2-bromothiazole by a procedure analogous to that described in Example 51b. Hydrogenation as described in Example 42b afforded 26 mg of the title compound as an oil.
출처 및 근거
- ORD 기록
- ord-ffb079f751d44e428571f9b1133aca67
- 출처 데이터셋
- uspto-grants-1998_01
- DOI