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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72519생성일: 2026년 10월 26일

Methyl 4-(1-aminocyclopropyl)benzoate hydrochloride → Methyl 4-(1-(2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72519

반응식

참여 물질

역할이름HCID투입량
반응물Methyl 4-(1-aminocyclopropyl)benzoate hydrochlorideHCID 66824369—
반응물2-(3-(3-(Trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acidHCID 86697876—
생성물Methyl 4-(1-(2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinamido)cyclopropyl)benzoateHCID 8669788073%

반응 단계

The title compound (D177) (113 mg) was prepared according to the experimental procedure described in Description 144 starting from 2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)-5-(trifluoromethyl)nicotinic acid (D126) (110 mg, 0.26 mmol) and methyl 4-(1-aminocyclopropyl)benzoate (D7) (59.31 mg, 0.26 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08828987B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-80562b2dd73a400fba157f05a2862491
출처 메모uspto-grants-2014_09