Sulfuryl chloride → 2-Chloro-5-(chloromethyl)-1,3-thiazole--hydrogen chloride (1/1)
반응식
[Cl:1][CH2:2][CH:3]=[CH:4][N:5]=[C:6]=[S:7].S(Cl)([Cl:11])(=O)=O>ClCCCl>[ClH:1].[Cl:11][C:6]1[S:7][C:3]([CH2:2][Cl:1])=[CH:4][N:5]=1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of 45 g of 3-chloroprop-1-enyl isothiocyanate in 90 ml of 1,2-dichloroethane, 50.5 g of sulphuryl chloride was added over 10 hours at -10° C. The reaction mixture was allowed to warm to 25° C. overnight, to complete the reaction. The solution was cooled to -15° C. and the product, a pale yellow solid, was isolated by filtration and washed with hexane. 38.2 g of 2-chloro-5-(chloromethyl) thiazole hydrochloride was thus obtained, having a melting point of 59°-61° C. and being a yield of 61.6%.
후처리
- customthe reaction
- temperatureThe solution was cooled to -15° C.
- customthe product, a pale yellow solid, was isolated by filtration
- washwashed with hexane
출처 및 근거
- ORD 기록
- ord-896c39ed1fdd4775a7cc875d55948e95
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05705652
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