Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate → Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate | HCID 24902824 | — |
| 반응물 | Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate | HCID 86697873 | — |
| 생성물 | Methyl 4-(1-(5-chloro-2-(3-((3-fluorophenoxy)methyl)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate | HCID 67958339 | 42.9% |
반응 단계
The title compound (D200) (38 mg) was prepared according to the experimental procedure described in Description 160 starting from tert-butyl 3-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate (D40) (100 mg, 0.338 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (61.8 mg, 0.169 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3c29f907b93249e18648fce3fe9ec4c5 |
| 출처 메모 | uspto-grants-2014_09 |