(R)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate → HCID 67958687, 화합물

HRID 72539

반응식

HRID 72539 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][CH:21]=1)[O:5][CH2:6][C@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](OC(C)(C)C)=O.ClC1[N:44]=[CH:43][C:42]([Cl:45])=[CH:41][C:24]=1[C:25]([NH:27][C:28]1([C:31]2[CH:40]=[CH:39][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:33][CH:32]=2)[CH2:30][CH2:29]1)=[O:26]>>[Cl:45][C:42]1[CH:43]=[N:44][C:12]([N:8]2[CH2:9][CH2:10][CH2:11][C@@H:7]2[CH2:6][O:5][C:4]2[CH:19]=[CH:20][CH:21]=[C:2]([F:1])[CH:3]=2)=[C:24]([CH:41]=1)[C:25]([NH:27][C:28]1([C:31]2[CH:32]=[CH:33][C:34]([C:35]([O:37][CH3:38])=[O:36])=[CH:39][CH:40]=2)[CH2:30][CH2:29]1)=[O:26]

참가 물질

3

반응물 2

HCID 22857708(R)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylateHCID 86697873Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate

생성물 1

HCID 67958687HCID 67958687, 화합물수율 90.3%

실험 절차

The title compound (D201) (80 mg) was prepared according to the experimental procedure described in Description 160 starting from (R)-tert-butyl 2-((3-fluorophenoxy)methyl)pyrrolidine-1-carboxylate (D42) (100 mg, 0.338 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D97) (61.8 mg, 0.169 mmol).

출처 및 근거

ORD 기록
ord-efbfd4fe022b42dea58474f74f96b715
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828987B2

연결된 노트

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