4-Fluorophenylboronic acid → 3-Chloro-4-(4-fluorophenyl)-2-(4-hydroxyphenyl)quinolin-6-ol

참여 물질

역할	이름	HCID	투입량
반응물	4-Fluorophenylboronic acid	HCID 285645	—
반응물	4-Bromo-3-chloro-2-(4-hydroxyphenyl)quinolin-6-ol	HCID 135502674	—
생성물	3-Chloro-4-(4-fluorophenyl)-2-(4-hydroxyphenyl)quinolin-6-ol	HCID 135442655	95%

반응 단계

This compound was prepared from 35a and 4-fluorophenylboronic acid according to method P. White solid; Yield: 95%; mp 295–296° C.; 1H-NMR (300 MHz, DMSO-d6) δ 6.55 (d, J=2.6 Hz, 1H), 6.87 (d, J=8.6 Hz, 2H), 7.31 (dd, J=9.1, 2.6 Hz, 1H), 7.45 (m, 4H), 7.57 (d, J=8.6 Hz, 2H), 7.92 (d, J=9.1 Hz, 1H), 9.73 (s, 1H), 10.07 (s, 1H); MS (ESI) m/z 364/366 ([M−H]−), 366/368 ([M+H]+); Anal. Calcd for C21H13ClFNO2: C: 68.96, H: 3.58, N: 3.83. Found: C: 68.19, H: 3.56, N: 3.74.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07084276B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-24f6748ad3254b64b7ff404d539083cd
출처 메모	uspto-grants-2006_08