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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72542생성일: 2026년 10월 26일

(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate → (S)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoate

https://huagongshe.com/reaction/72542

반응식

참여 물질

역할이름HCID투입량
반응물(S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylateHCID 67958745—
반응물Methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoateHCID 86697873—
생성물(S)-methyl 4-(1-(5-chloro-2-(3-(3-fluorophenoxy)pyrrolidin-1-yl)nicotinamido)cyclopropyl)benzoateHCID 86697882111.9%

반응 단계

The title compound (D204) (101 mg) was prepared according to the experimental procedure described in Description 160 starting from (S)-tert-butyl 3-(3-fluorophenoxy)pyrrolidine-1-carboxylate (D46) (100 mg, 0.355 mmol) and reacting in the second step with methyl 4-(1-(2,5-dichloronicotinamido)cyclopropyl)benzoate (D) (D021/056/3) (65 mg, 0.177 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08828987B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-18cf7095cbb0425bb13a39424d2ad15f
출처 메모uspto-grants-2014_09