2-Aminophenol → 2-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide

HRID 72561

반응식

HRID 72561 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[Br:9][C:10]([CH3:15])([CH3:14])[C:11](Br)=[O:12].C(N(CC)CC)C>C(Cl)Cl>[Br:9][C:10]([CH3:15])([CH3:14])[C:11]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8])=[O:12]

참가 물질

5

반응물 3

HCID 58012-AminophenolHCID 8471TriethylamineHCID 886852-Bromo-2-methylpropionyl bromide

생성물 1

HCID 146849852-bromo-N-(2-hydroxyphenyl)-2-methylpropionamide수율 921%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

To a stirred solution of 2-aminophenol (10 g, 9.2 mmol) in DCM (92 mL) at 0° C. was added 2-bromoisobutyryl bromide (11.4 mL, 9.17 mmol) followed by triethyl amine (12.7 mL, 9.2 mmol) and stirred the reaction mixture at 0° C. for 4 h. Reaction mixture was diluted with DCM 100 mL and then washed with water 100 mL dried over sodium sulfate, concentrated on rotavap to give 2-Bromo-N-(2-hydroxy-phenyl)-2-methyl-propionamide (21.8 g) brown solid which was used for next reaction without purification

후처리

  1. customReaction mixture
  2. washwashed with water 100 mL
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated on rotavap

출처 및 근거

ORD 기록
ord-f70754058db14c05b3f9a06965862770
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828951B2

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