참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Beta-Aminoisobutyric Acid | HCID 64956 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
반응 단계
A solution of 41.7 ml of chloroformic acid benzyl ester (90%) in toluene is added to 25 g of 3-amino-2(R,S)-methylpropionic acid in 533 ml of 1N sodium hydroxide at 0° C. The reaction mixture is then stirred for 30 minutes at 0° C. After the addition of 400 ml of diethyl ether, the aqueous phase is removed and 140 ml of 4N hydrochloric acid are added. The crude title compound is obtained from the organic phase by extraction with diethyl ether: Rf (dichloromethane/methanol=8:2)=0.41.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05705658 |
|---|
| 출처 데이터셋 | uspto-grants-1998_01 |
|---|
| ORD ID | ord-fc361ff62aed4ddea9fce955975be3a7 |
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| 출처 메모 | uspto-grants-1998_01 |
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