Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → n-Acetyl-4-(2-tert-butoxycarbonylaminoethyl)-piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-(2-Aminoethyl)piperidine, 4-BOC protected | HCID 1501849 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | n-Acetyl-4-(2-tert-butoxycarbonylaminoethyl)-piperidine | HCID 21458620 | — |
반응 단계
0.5 g of 4-(2-tert-butoxycarbonylaminoethyl)-piperidine and 0.61 ml of triethylamine are dissolved in 5 ml of dichloromethane and, at 0° C., 0.22 ml of acetyl chloride is added. The reaction mixture is stirred at room temperature for 7 hours and then washed with water. The organic phase is concentrated by evaporation and purified by FC (10 g of silica gel, ethyl acetate/methanol=9:1). The title compound is obtained: Rf (ethyl acetate/methanol=9:1)=0.39.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05705658 |
| 출처 데이터셋 | uspto-grants-1998_01 |
| ORD ID | ord-1e0dad00f5eb4065a2020491b3ae2166 |
| 출처 메모 | uspto-grants-1998_01 |