Iodine → HCID 12786936, 화합물

HRID 725690노트

반응식

HRID 725690 반응식
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=[O:3])[CH3:2].[I:11]I.C(O)(C)C.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[I-:11].[Br:10][C:6]1[N:5]=[C:4]([C:1](=[O:3])[CH2:2][N+:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 4

HCID 807IodineHCID 1049PyridineHCID 3776IsopropanolHCID 112985782-Acetyl-6-bromopyridine

생성물 1

HCID 12786936HCID 12786936, 화합물

실험 절차

To a stirred solution of 2-acetyl-6-bromopyridine (100 g; 0.5 mole) in 600 mL pyridine was added iodine (127 g; 0.5 mole). The mixture was heated on a steam bath for 45 minutes, and the product crystallized on cooling. The solid was filtered and the light yellow crystalline cake was rinsed twice with methylene chloride. After drying, 183 g (90%) was obtained. MP 176°-178° C.; silica gel TLC system: 95acetone: 5 isopropanol.

후처리

  1. temperatureThe mixture was heated on a steam bath for 45 minutes
  2. customthe product crystallized
  3. temperatureon cooling
  4. filtrationThe solid was filtered
  5. washthe light yellow crystalline cake was rinsed twice with methylene chloride
  6. customAfter drying
  7. custom183 g (90%) was obtained

출처 및 근거

ORD 기록
ord-fdae55a513b742c28bcefa581f5a4824
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05707603

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