methyl (E)-3-(4-cyanophenyl)prop-2-enoate → Methyl 3-(4-cyanophenyl)propanoate
반응식
[C:1]([C:3]1[CH:14]=[CH:13][C:6](/[CH:7]=[CH:8]/[C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1)#[N:2]>C1(C)C=CC=CC=1.[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[C:1]([C:3]1[CH:14]=[CH:13][C:6]([CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:5][CH:4]=1)#[N:2]참가 물질
4
실험 절차
To a solution of methyl p-cyano-trans-cinnamate (13.6 g, 73 mmol) in toluene (485 mL) was added 5% Pd/BaSO4 (2.7 g). After 9 hours under hydrogen gas at 4 bar (60 psi), the solution was filtered, concentrated in vacuo and chromatographed over silica gel, eluting with a step gradient of hexanes through 30% ethyl acetate/hexanes. The product containing fractions were combined and concentrated to give 10.6 g (77%) of colorless oil.
후처리
- filtrationthe solution was filtered
- concentrationconcentrated in vacuo
- customchromatographed over silica gel
- washeluting with a step gradient of hexanes through 30% ethyl acetate/hexanes
- additionThe product containing fractions
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e71f1dba37cb4cc69a4535bea4048212
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05707966
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