Methyl 3-oxoheptanoate → HCID 178441198, 화합물

HRID 725815노트

반응식

HRID 725815 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1.O=[C:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10](OC)=[O:11]>C1(C)C=CC=CC=1>[CH2:14]([C:8]1[CH:9]=[C:10]([OH:11])[N:3]2[N:4]=[CH:5][CH:6]=[C:2]2[N:1]=1)[CH2:15][CH2:16][CH3:17]

참가 물질

4

반응물 2

HCID 546075Methyl 3-oxoheptanoateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178441198HCID 178441198, 화합물수율 80.1%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

A solution of 100 g of 3-aminopyrazole and 190 g of methyl 3-oxoheptanoate in 120 ml of toluene was refluxed with heating at 100° C. for 3 hours and then cooled. Toluene was distilled off under reduced pressure and diethyl ether was added to the residue. The crystals precipitated were collected and washed with diethyl ether and acetonitrile to provide 184 g of 5-n-butyl-7-hydroxypyrazolo[1,5-a]pyrimidine as colorless crystals.

후처리

  1. temperaturecooled
  2. distillationToluene was distilled off under reduced pressure and diethyl ether
  3. additionwas added to the residue
  4. customThe crystals precipitated
  5. customwere collected
  6. washwashed with diethyl ether and acetonitrile

출처 및 근거

ORD 기록
ord-71d73ca6f2c044b58efa7b273705b756
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05707997

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