4-Bromo-2-nitro-cyclopropylbenzene → Tranylcypromine
반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[N+:11]([O-])=O)=[CH:4][CH:3]=1>C(O)C.[Pd]>[NH2:11][CH:9]1[CH2:10][CH:8]1[C:5]1[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=1참가 물질
4
실험 절차
3.5 g of 4-bromo-2-nitro-cyclopropylbenzene are dissolved in 30 ml of ethanol and, after addition of 0.5 g of palladium-on-charcoal (10%), are hydrogenated in a Parr apparatus at room temperature under a hydrogen pressure of 5 bar for 2.5 hours. After cooling, the solvent is distilled off in a rotary evaporator and the residue is rendered alkaline with 1N sodium hydroxide solution and extracted three times with 50 ml of ether each time. The combined organic phases are dried over sodium sulphate, the solvent is distilled off in a rotary evaporator and the residue is purified by column chromatography.
후처리
- customare hydrogenated in a Parr apparatus at room temperature under a hydrogen
- customfor 2.5 hours
- temperatureAfter cooling
- distillationthe solvent is distilled off in a rotary evaporator
- extractionextracted three times with 50 ml of ether each time
- dry with materialThe combined organic phases are dried over sodium sulphate
- distillationthe solvent is distilled off in a rotary evaporator
- customthe residue is purified by column chromatography
출처 및 근거
- ORD 기록
- ord-d9f7ea18dee34b04aa88c425d1b95bf5
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05707989
반응 노트
불러오는 중…