Water → N-[2-(2,6-dimethoxyquinolin-4-yl)ethyl]acetamide

HRID 725890노트

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HRID 725890 반응식
Cl[C:2]1[CH:11]=[C:10]([CH2:12][CH2:13][NH:14][C:15](=[O:17])[CH3:16])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:18][CH3:19])[CH:8]=2)[N:3]=1.[CH3:20][O-:21].[Na+].O>CO>[CH3:20][O:21][C:2]1[CH:11]=[C:10]([CH2:12][CH2:13][NH:14][C:15](=[O:17])[CH3:16])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:18][CH3:19])[CH:8]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9860467N-[2-(2-chloro-6-methoxyquinolin-4-yl)ethyl]acetamideHCID 10942334Sodium Methoxide

생성물 1

HCID 19709971N-[2-(2,6-dimethoxyquinolin-4-yl)ethyl]acetamide수율 52.4%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
60 °C

실험 절차

A mixture of N-[2-(2-chloro-6-methoxyquinolin-4-yl)ethyl]acetamide (0.9 g, 3.2 mmol) and sodium methoxide (30 g, 28% methanol solution) in methanol (20 ml) was stirred at 60° C. overnight. The reaction mixture was poured into water, and the organic layer was extracted with ethyl acetate. The extract was washed with saturated brine and water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting residue was purified by column chromatography on silica gel (ethyl acetate) and recrystallized from a mixed solvent of ethyl acetate and hexane to obtain the title compound (0.46 g, 52%).

후처리

  1. extractionthe organic layer was extracted with ethyl acetate
  2. washThe extract was washed with saturated brine and water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. customThe resulting residue was purified by column chromatography on silica gel (ethyl acetate)
  6. customrecrystallized from a mixed solvent of ethyl acetate and hexane

출처 및 근거

ORD 기록
ord-a090178fb9ce4ddb909b86eefa7e77e7
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05708005

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