1H-Indol-5-amine, 3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)- → 3-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

HRID 725962노트

반응식

HRID 725962 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1>CO.[Pd].CCCCCC>[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]1

참가 물질

5

반응물 1

HCID 111488671H-Indol-5-amine, 3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-

생성물 1

HCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8058Hexane용매

실험 절차

To a solution of 11.3 gm (50 mMol) 5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole in 250 mL methanol were added 3.0 gm 5% palladium on carbon. The mixture was hydrogenated at room temperature under an initial hydrogen pressure of 60 p.s.i. for 18 hours. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to give a dark gum which was slurried in hexane to give the title compound as a brown solid.

후처리

  1. customwas hydrogenated at room temperature under an initial hydrogen
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate concentrated under reduced pressure
  4. customto give a dark gum which

출처 및 근거

ORD 기록
ord-dbc998b214d84346801f744f10d3e7d0
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05708008

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