Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- → 3-(2-Chloro-4-fluorophenyl)propanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propenoic acid, 3-(2-chloro-4-fluorophenyl)- | HCID 2725065 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Platinum oxide monohydrate | HCID 86587499 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(2-Chloro-4-fluorophenyl)propanoic acid | HCID 11769583 | 101.4% |
반응 단계
A mixture of 2-chloro-4-fluorocinnamic acid (22.9 g, 0.11 mol) and platinum oxide hydrate (0.5 g, EM Scientific) in 95% ethanol (140 ml) was placed on a Parr hydrogenation apparatus. After the appropriate amount of hydrogen was taken up, the catalyst was filtered and the mixture was concentrated in vacuo to give 22.6 g (98%) of 3-(2-chloro-4-fluorophenyl)propanoic acid as a purple solid. This material was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05708033 |
| 출처 데이터셋 | uspto-grants-1998_01 |
| ORD ID | ord-42500ebc25824cfa82c7d3a5689ba03c |
| 출처 메모 | uspto-grants-1998_01 |