1-(2-Methoxyphenyl)piperazine → Nan 190

HRID 72632노트

반응식

HRID 72632 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH2:11][CH2:10]1.BrCCCCN1[C:29](=[O:30])[C:28]2=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]2[C:26]1=[O:35].COC1C=CC=CC=1N1CCNCC1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[C:29](=[O:30])[C:28]3=[CH:31][CH:32]=[CH:33][CH:34]=[C:27]3[C:26]2=[O:35])[CH2:13][CH2:14]1

참가 물질

4

반응물 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 93575N-(4-Bromobutyl)phthalimideHCID 109999031-(4-Aminobutyl)-4-(2-methoxyphenyl)piperazine

생성물 1

HCID 4431Nan 190수율 84.3%

실험 절차

4-[4-(2-methyloxyphenyl)piperazinyl]butylamine: according to the method of claim 1, N-(4-bromobutyl)phthalimide and 2-methyloxyphenyl-piperazine was used in reaction to produce N-{4-[4-(2-methyloxyphenyl)piperazinyl]butyl}phthalimide, which was then reacted with hydrazine hydrate. The yield was: 84.3%. Hydrochloride salt had a mp: 173-175° C.

후처리

  1. customwas used in reaction

출처 및 근거

ORD 기록
ord-00c4f5ce7b76428bacf0d4d57cbaa035
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829001B2

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