Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isoquinoline-1-carboxylic acid → Decahydro-isoquinoline-1-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Rhodium | HCID 23948 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Decahydro-isoquinoline-1-carboxylic acid | HCID 5232405 | 56.8% |
반응 단계
A solution of 1-isoquinolinecarboxylic acid (50 g, 0.288 mol) in EtOH (150 mL) and 60 mL of 5N HCl was reduced over 5% Rh/Al2O3 (14 g) at 52 bar (750 psi) of hydrogen in a high pressure apparatus at 50° C. for 17 hours. The reaction mixture was filtered through a pad of diatomaceous earth, and the filtrate was concentrated in vacuo. The solid was triturated with water, filtered and dried to give DL-perhydro-1-isoquinolinecarboxylic acid (DL-1-Piq-OH) (30 g, 48%) FD-MS 184 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05710130 |
| 출처 데이터셋 | uspto-grants-1998_01 |
| ORD ID | ord-c9a2c54f73f345eda3a5143057db0ab0 |
| 출처 메모 | uspto-grants-1998_01 |