Piperazine → 1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

HRID 72673

반응식

HRID 72673 반응식
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=1>C1COCC1>[F:15][C:14]([F:17])([F:16])[C:11]1[CH:12]=[CH:13][C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 923422-Chloro-5-(trifluoromethyl)pyridine

생성물 1

HCID 6676181-(5-Trifluoromethyl-pyridin-2-yl)-piperazine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

후처리

  1. additionSubsequently the reaction mixture was poured
  2. customonto crushed ice
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with sodium bicarbonate
  5. customevaporated

출처 및 근거

ORD 기록
ord-2539442d428d4383a6d9b930dc5daea0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08828999B2

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