Triethylamine → HCID 19707506, 화합물

HRID 726748

반응식

HRID 726748 반응식
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[CH2:10][CH2:11][NH2:12])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:25][O:26][CH2:27][C:28](Cl)=[O:29]>O1CCCC1>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH2:10][CH2:11][NH:12][C:28](=[O:29])[CH2:27][O:26][CH3:25])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 96623Methoxyacetyl chlorideHCID 112763943-Cyclopentyloxy-4-methoxyphenethylamine

생성물 1

HCID 19707506HCID 19707506, 화합물수율 38.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-cyclopentyloxy-4-methoxyphenethylamine (0.2 g, 0.85 mmol) in tetrahydrofuran (6 mL) was cooled to 0° C. and was treated with triethylamine (0.13 mL, 0.92 mmol) and methoxyacetyl chloride (0.078 mL, 0.85 mmol). The reaction was stirred under an argon atmosphere for 0.25 h, then was partitioned between methylene chloride and water. The extract was dried (potassium carbonate) and evaporated. Purification by flash chromatography, eluting with 5% methanol/chloroform, provided an oil; additional 0.1 g of impure product also obtained).

후처리

  1. customwas partitioned between methylene chloride and water
  2. dry with materialThe extract was dried (potassium carbonate)
  3. customevaporated
  4. customPurification by flash chromatography
  5. washeluting with 5% methanol/chloroform
  6. customprovided an oil

출처 및 근거

ORD 기록
ord-91f4cebc236d47f8883b51e796df83af
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05710180

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