Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dibromopyridine → 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dibromopyridine | HCID 12274 | — |
| 반응물 | 4-Aminotetrahydropyran | HCID 419223 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 6-Bromo-N-(tetrahydro-2H-pyran-4-yl)pyridin-2-amine | HCID 63962797 | 0% |
반응 단계
to 2,6-dibromopyridine (100 mg, 0.42 mmol), 4-Aminotetrahydropyran (42.7 mg, 0.42 mmol) in dioxane (3 mL) while bubbling N2 was added Xantphos (24.43 mg, 0.04 mmol), CS2CO3 (316 mg, 0.97 mmol) and palladium(II) acetate (9.48 mg, 0.04 mmol). This was heated in a microwave at 130 oC for 30 mins. A small peak corresponding to product was obseved. Discontinued
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|---|
| ORD ID | ord-13cef69f8e724020954e5476c0d66794 |
| 출처 메모 | 750 AstraZeneca ELN dataset |