(2S,4S)-4-(4-methoxybenzylthio)-2-[(3S)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine hydrochloride → (2S,4S)-4-(4-Methoxybenzylthio)-2-[(3S)-4-(N-4-nitrobenzyloxycarbonylacetimidoyl)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

HRID 727625노트

반응식

HRID 727625 반응식
Cl.[CH3:2][O:3][C:4]1[CH:38]=[CH:37][C:7]([CH2:8][S:9][C@@H:10]2[CH2:14][N:13]([C:15]([O:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=3)=[O:16])[C@H:12]([C:28]([N:30]3[CH2:35][CH2:34][NH:33][C@@H:32]([CH3:36])[CH2:31]3)=[O:29])[CH2:11]2)=[CH:6][CH:5]=1.[N+:39]([C:42]1[CH:55]=[CH:54][C:45]([CH2:46][O:47][C:48]([NH:50][C:51](=N)[CH3:52])=[O:49])=[CH:44][CH:43]=1)([O-:41])=[O:40]>C(#N)C>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:8][S:9][C@@H:10]2[CH2:14][N:13]([C:15]([O:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([N+:25]([O-:27])=[O:26])=[CH:23][CH:24]=3)=[O:16])[C@H:12]([C:28]([N:30]3[CH2:35][CH2:34][N:33]([C:51](=[N:50][C:48]([O:47][CH2:46][C:45]4[CH:54]=[CH:55][C:42]([N+:39]([O-:41])=[O:40])=[CH:43][CH:44]=4)=[O:49])[CH3:52])[C@@H:32]([CH3:36])[CH2:31]3)=[O:29])[CH2:11]2)=[CH:37][CH:38]=1

참가 물질

4

반응물 2

HCID 67585387(2S,4S)-4-(4-methoxybenzylthio)-2-[(3S)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine hydrochlorideHCID 140352007HCID 140352007, 화합물

생성물 1

HCID 88299347(2S,4S)-4-(4-Methoxybenzylthio)-2-[(3S)-4-(N-4-nitrobenzyloxycarbonylacetimidoyl)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine수율 30.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2.26 g of (2S,4S)-4-(4-methoxybenzylthio)-2-[(3S)-3-methylpiperazin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine hydrochloride [prepared as described in step (i) above] were mixed with 1.14 g of N-(4-nitrobenzyloxycarbonyl)acetamidine and 45 ml of acetonitrile, and the mixture was heated under reflux for 16 hours. At the end of this time, the reaction mixture was worked up and purified by the same procedure as described in Preparation 1(ii), to give 922 mg of the title compound, as a powder.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 16 hours
  3. custompurified by the same procedure
  4. customas described in Preparation 1(ii)

출처 및 근거

ORD 기록
ord-eaf7e7548b7b4b85a6ebd8f2bef5f431
출처 데이터셋
uspto-grants-1998_01
특허 번호
US05712267

반응 노트

불러오는 중…