Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethoxyethylamine → N-(2-ethoxyethyl)-3-fluoro-4-nitrobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethoxyethylamine | HCID 66970 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Fluoro-4-nitrobenzoic acid | HCID 230653 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(2-ethoxyethyl)-3-fluoro-4-nitrobenzamide | HCID 59198706 | — |
반응 단계
3-Fluoro-4-nitrobenzoic acid 5.55 g, 2-ethoxyethylamine 3.15 mL, N,N-diisopropylethylamine 5.23 mL, 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride 8.63 g, 1-hydroxybenzotriazole monohydrate 5.96 g and acetonitrile 77 mL were mixed and stirred for 19 hours. The reaction liquid was poured in diluted hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, saturated aqueous sodium hydrogencarbonate solution and saturated brine, by the order stated, and dried over magnesium sulfate. Distilling the solvent off, 6.86 g of the title compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829000B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-c289596415db46dba95edc6d7a6a7ad7 |
| 출처 메모 | uspto-grants-2014_09 |