Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Pyridinemethanamine → 3-Fluoro-4-nitro-N-(3-pyridylmethyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Pyridinemethanamine | HCID 31018 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Fluoro-4-nitrobenzoic acid | HCID 230653 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 3-Fluoro-4-nitro-N-(3-pyridylmethyl)benzamide | HCID 59198667 | — |
반응 단계
3-Fluoro-4-nitrobenzoic acid 2.78 g, 3-pyridylmethylamine 1.55 mL, N,N-diisopropylethylamine 2.61 mL, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride 4.31 g, 1-hydroxybenzotriazole monohydrate 2.98 g and acetonitrile 39 mL were mixed and stirred for 20 hours. The reaction liquid was poured in saturated aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine by the order stated, and dried over magnesium sulfate. Distilling the solvent off, 4.09 g of the title compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829000B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b2ee502842fb410a956edc914c523915 |
| 출처 메모 | uspto-grants-2014_09 |