참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxylate | HCID 1113514 | — |
| 반응물 | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Ethyl 5-[(E)-2-ethoxycarbonylvinyl]-3-methyl-1H-pyrrole-2-carboxylate | HCID 59198650 | 47.7% |
반응 단계
Ethyl 5-formyl-3-methyl-1H-pyrrole-2-carboxyate 470 mg, monoethyl malonate 378 mg, piperidine 0.05 mL and pyridine 6 mL were mixed and stirred at 100° C. for 38 hours. Ice water was added to the reaction liquid and the precipitate was recovered by filtration. The precipitate was washed with water and dried in flowing air under heating to provide 311 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08829000B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-fb2dddac9b4b492ab2f73cd7baa61606 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
