Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 2,6-Difluorophenylacetyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2,6-Difluorophenylacetic acid | HCID 123585 | — |
| 생성물 | 2,6-Difluorophenylacetyl chloride | HCID 2758321 | — |
반응 단계
75.3 g (0.44 mol) of 2,6-difluorophenylacetic acid are dissolved in 96 ml (156.5 g; 1.32 mol) of thionyl chloride, stirred for 1 hour at 60° and then heated under reflux for 2 hours. The excess thionyl chloride is then distilled off and the residue is fractionated, yielding 79.5 g (95% of the theoretical yield) of 2,6-difluorophenylacetyl chloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05045556 |
| 출처 데이터셋 | uspto-grants-1991_09 |
| ORD ID | ord-6c85fe6bc8664cbe91c309939c981546 |
| 출처 메모 | uspto-grants-1991_09 |