4-[1-(1-Imidazolyl)-butyl]-benzonitrile → 4-[1-(1-Imidazolyl)butyl]-benzaldehyde

HRID 727848노트

반응식

HRID 727848 반응식
[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#N)=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)=[O:19].O>[Al].[Ni]>[N:1]1([CH:6]([C:10]2[CH:17]=[CH:16][C:13]([CH:14]=[O:19])=[CH:12][CH:11]=2)[CH2:7][CH2:8][CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 145143624-[1-(1-Imidazolyl)-butyl]-benzonitrileHCID 18673298Formic acid--water (1/1)

생성물 1

HCID 145143774-[1-(1-Imidazolyl)butyl]-benzaldehyde

시약·촉매·용매 1

HCID 6336846Nickel aluminide촉매

실험 절차

10 g of nitrile of example 4 is refluxed with 10 g of aluminum nickel alloy in 150 ml of formic acid/water (75:25) for 1 hour. It is filtered on kieselguhr, the filtrate is alkalized with solid potassium carbonate, 100 ml of aqueous ammonia is added and extracted with ether. After drying and concentration by evaporation of the ether, it is distilled on a bulb tube; 9.1 g of 4-[1-(1-imidazolyl)butyl]-benzaldehyde is obtained, melting 200° C./0.03 mbar.

후처리

  1. filtrationIt is filtered on kieselguhr
  2. additionis added
  3. extractionextracted with ether
  4. customAfter drying
  5. concentrationconcentration
  6. customby evaporation of the ether, it
  7. distillationis distilled on a bulb tube

출처 및 근거

ORD 기록
ord-a1e772603d33436ba04f83519ca41b85
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05045558

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