Sodium Cyanide → 3-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile

HRID 728062노트

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HRID 728062 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14])[CH2:6]Cl.[C-:17]#[N:18].[Na+]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][C:17]#[N:18])[CH:8]=[C:9]([S:15][CH3:16])[C:10]=1[O:11][CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 15044966HCID 15044966, 화합물

생성물 1

HCID 150449673-Methoxy-5-methylthio-4-propoxyphenyl acetonitrile수율 95%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 16 g of 3-methoxy-5-methylthio-4-propoxybenzyl chloride in 100 ml of dry DMF was added 5 g (0.10 mole) sodium cyanide. The mixture was stirred for about 48 hours at room temperature under N2. The solution was filtered, and the filtrate was concentrated under vacuum. The residue was purified by flash column chromatography to yield 14.5 g of 3-methoxy-5-methylthio-4-propoxyphenyl acetonitrile as an oil. (95% yield).

후처리

  1. filtrationThe solution was filtered
  2. concentrationthe filtrate was concentrated under vacuum
  3. customThe residue was purified by flash column chromatography

출처 및 근거

ORD 기록
ord-96dc13ddc31b44d1927471b29f0b28b2
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05047420

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