Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nilotinib Hydrochloride Anhydrous → Nilotinib
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nilotinib Hydrochloride Anhydrous | HCID 16006490 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Nilotinib | HCID 644241 | — |
반응 단계
4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide hydrochloride (14 g) is dissolved in 1,000 g of methanol in a hot water bath. The solution is spray dried in a Buchi Mini spray at about 65° C. to form the amorphous hydrochloride salt of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829015B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e4e78fc2852f470bbd32a2eea39b6bc6 |
| 출처 메모 | uspto-grants-2014_09 |