Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 72854생성일: 2026년 10월 27일
4-Hydroxy-4-methylcyclohexanone → (4-Methoxy-4 methyl-cyclohexylidene)-acetic acid methyl ester
https://huagongshe.com/reaction/72854
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Hydroxy-4-methylcyclohexanone | HCID 28539 | — |
| 반응물 | Trimethyl phosphonoacetate | HCID 80029 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | (4-Methoxy-4 methyl-cyclohexylidene)-acetic acid methyl ester | HCID 66742062 | — |
반응 단계
A mixture of trimethyl phosphonoacetate (9.11 mL, 56 mmol) and (40 mL, 64 mmol) of n-BuLi (1.6N) in DME (60 mL) is stirred for 10 minutes at 0° C. 4-Hydroxy-4-methyl-cyclohexanone (8 g, 56 mmol) was added and the mixture stirred 2.5 hours at 0° C. until TCL indicated complexion of the reaction. Product was obtained after extraction with dichloromethane (7.71 g, 69%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08829029B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-d765b0a07c0e4665acc96698a2b2a4ee |
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| 출처 메모 | uspto-grants-2014_09 |
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