Acetylpyrazine → Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazide

HRID 728545

반응식

HRID 728545 반응식
[C:1]([C:4]1[CH:9]=[N:8][CH:7]=[CH:6][N:5]=1)(=O)[CH3:2].[C:10]([NH:14][NH2:15])(=[O:13])[CH2:11][CH3:12]>C(O)C>[N:5]1[CH:6]=[CH:7][N:8]=[CH:9][C:4]=1[C:1](=[N:15][NH:14][C:10](=[O:13])[CH2:11][CH3:12])[CH3:2]

참가 물질

4

반응물 2

HCID 30914AcetylpyrazineHCID 79890Propionylhydrazine

생성물 1

HCID 54558617Propanoic acid [1-(2-pyrazinyl)ethylidene]hydrazide수율 64.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 6.11 gm (0.05 mole) of 2-acetylpyrazine, 4.41 gm (0.05 mole) of propanoic acid hydrazide and 100 ml of absolute ethanol is refluxed 10 hr. The mixture is cooled. The white crystals which deposit are collected and dried to yield 6.17 gm (64%) of the title compound having a melting point of 181.3° C.

후처리

  1. temperatureis refluxed 10 hr
  2. temperatureThe mixture is cooled
  3. customThe white crystals which deposit are collected
  4. customdried

출처 및 근거

ORD 기록
ord-634a163bfca84dbcb8aac450056b0f69
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05049561

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