Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Toluenesulfonyl chloride → N,N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Diethanolamine | HCID 8113 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N,N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide | HCID 267409 | 85% |
반응 단계
A solution of 32.5 g (0.31 mole) of diethanolamine in 60 cm3 of pyridine are added slowly to a solution of 185 g (0.97 mole) of tosyl chloride in 220 cm3 of pyridine at 0° C. so that the temperature does not exceed 5° C. After the addition is complete, the mixture is maintained at this temperature for 1 h, then it is poured into 220 cm3 of ice-cold water with vigorous stirring. After filtration, washing and drying 148.4 g of precipitate are obtained (yield 85%; Rf=0.6 silica/CH2Cl2 /acetone/98/2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05049667 |
| 출처 데이터셋 | uspto-grants-1991_09 |
| ORD ID | ord-5beef8f61e2749169ab4d1b52e210bd8 |
| 출처 메모 | uspto-grants-1991_09 |