Triethylamine → N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

HRID 728814

반응식

HRID 728814 반응식
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:26](Cl)(=[O:29])[CH2:27][CH3:28]>C1COCC1>[C:13]1([CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10][NH:11][C:26](=[O:29])[CH2:27][CH3:28])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 6394114N1,N1-Dibenzylethane-1,2-diamine

생성물 1

HCID 54327882N-[2-[bis(Phenylmethyl)amino]ethyl]-propanamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a chilled solution of 5.0 g (21 mmol) N,N-dibenzylethylenediamine and 30mL (21 mmol) triethylamine in 20 mL THF is added 1.8 mL (21 mmol) propionylchloride, dropwise. The temperature of the reaction mixture is maintained below 0° C. during addition. The reaction mixture is stirred for 30minutes at 0° C. After this time, the reaction mixture is filtered and the solvents are evaporated to give the product which can be purified via column chromatography.

후처리

  1. temperatureThe temperature of the reaction mixture is maintained below 0° C. during addition
  2. filtrationAfter this time, the reaction mixture is filtered
  3. customthe solvents are evaporated
  4. customto give the product which
  5. customcan be purified via column chromatography

출처 및 근거

ORD 기록
ord-6c796ddafef5454ba34e40ccd9db3930
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051423

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