1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol → 1-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]-3-phenoxy-2-propanol

HRID 728833노트

반응식

HRID 728833 반응식
[N:1]1([C:6]2[CH:33]=[CH:32][C:9]([O:10][CH2:11][CH2:12][N:13](CC3C=CC=CC=3)[CH2:14][CH:15]([OH:24])[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>CO.[Pd]>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([O:10][CH2:11][CH2:12][NH:13][CH2:14][CH:15]([OH:24])[CH2:16][O:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:32][CH:33]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 1

HCID 539690031-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol

생성물 1

HCID 147399051-[[2-[4-(1H-Imidazol-1-yl)phenoxy]ethyl]amino]-3-phenoxy-2-propanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 5.5 g (12.4 mmol) 1-[[2-[4-(1H-imidazol-1-yl)phenoxy]ethyl](phenylmethyl)amino]-3-phenoxy-2-propanol in 25 mL methanol is suspended 1.0 g 10% palladium on carbon. The reaction mixture is hydrogenated at 50 psi in a Parr Hydrogenator. Follow the progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1). At the completion of the reaction, thecatalyst is filtered and the solvents are removed in vacuo. The isolated oil is taken up in methylene chloride, dried over anhydrous Na2SO4, filtered and the solvents are removed to give the title compound.

후처리

  1. customthe progress of the reaction by thin-layer chromatography on silica gel (methylene chloride:methanol, 9:1)
  2. customAt the completion of the reaction, thecatalyst
  3. filtrationis filtered
  4. customthe solvents are removed in vacuo
  5. dry with materialdried over anhydrous Na2SO4
  6. filtrationfiltered
  7. customthe solvents are removed

출처 및 근거

ORD 기록
ord-8fdf8ab75a6a46d69ddb89040956c604
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051423

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