3-Methoxyaniline → N-(3-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine hydrochloride

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:9])[CH:6]=[CH:7][CH:8]=1.Cl.[Cl:11][CH2:12][CH2:13][NH:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[ClH:11].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:9][CH2:12][CH2:13][NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

반응물 2

HCID 108243-Methoxyaniline

HCID 13054189Benzenemethanamine, N-(2-chloroethyl)-, hydrochloride (1:1)

생성물 1

HCID 19755023N-(3-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine hydrochloride

실험 절차

Combine 3-methoxybenzenamine (81.2 g, 0.66 mol) with N-(2-chloroethyl)-benzenemethanamine hydrochloride (45.3 g, 0.22 mol) and heat to 190° C. for 13 h. Add methylene chloride to precipitate a solid. Filter the solid and wash with methylene chloride. Triturate the solid with 100 mL of ethanol, filter the solid and wash with ethanol to give the title compound.

후처리

customAdd methylene chloride to precipitate a solid
filtrationFilter the solid
washwash with methylene chloride
customTriturate the solid with 100 mL of ethanol
filtrationfilter the solid
washwash with ethanol

출처 및 근거

ORD 기록: ord-ea00a29a82bd4dcab40ac011449b56ee
출처 데이터셋: uspto-grants-1991_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05051422

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