Ammonia → Benzo-1,2,3-thiadiazole-7-carboxylic acid amide

HRID 729002

반응식

HRID 729002 반응식
[NH3:1].C[O:3][C:4]([C:6]1[C:14]2[S:13][N:12]=[N:11][C:10]=2[CH:9]=[CH:8][CH:7]=1)=O>O1CCCC1>[S:13]1[C:14]2[C:6]([C:4]([NH2:1])=[O:3])=[CH:7][CH:8]=[CH:9][C:10]=2[N:11]=[N:12]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 1794011,2,3-Benzothiadiazole-7-carboxylic acid, methyl ester

생성물 1

HCID 22403364Benzo-1,2,3-thiadiazole-7-carboxylic acid amide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In an autoclave, under pressure and at room temperature, 17 g of ammonia ispassed into a solution of 19.4 g of benzo-1,2,3-thiadiazole-7-carboxylic acid methyl ester in 70 ml of tetrahydrofuran. The solution is then heatedand maintained at 80°-90° C. for approximately 20 hours, an internal pressure of 55·105Pa max. building up. Partial concentration by evaporation is then carried out and the resulting precipitate is filtered off, washed with cold tetrahydrofuran and dried. 14.9 g of beige crystals having a melting point of 270°-272°C. are obtained.

후처리

  1. customat room temperature
  2. temperatureThe solution is then heatedand maintained at 80°-90° C. for approximately 20 hours
  3. concentrationPartial concentration
  4. customby evaporation
  5. filtrationthe resulting precipitate is filtered off
  6. washwashed with cold tetrahydrofuran
  7. customdried
  8. customare obtained

출처 및 근거

ORD 기록
ord-bb81936b7eed4b80be88f27f04375034
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051436

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