Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Toluidine hydrochloride → SK&F 96079
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Toluidine hydrochloride | HCID 12484 | — |
| 반응물 | 4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline | HCID 3332664 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | SK&F 96079 | HCID 196776 | 22% |
반응 단계
2-Methyl-3-(2-chloroethyl)-4-chloro-8-methoxyquinoline (8.37 g, 31 mmol) and 2-methylaniline hydrochloride (4.45 g, 31 mmol) in 1-butanol (100 ml) were heated at reflux for 5 days, then the solvent evaporated, the crude product taken up in dichloromethane, washed with aqueous sodium bicarbonate, dried and evaporated. Chromatography (silica gel, 2% methanolic ammonia in dichloromethane) and recrystallisation from aqueous ethanol gave 1-(2-methylphenyl)-4-methyl-6-methoxy-2,3-dihydropyrrolo[3,2-c]quinoline (2.04 g, 22 %), m.p. 182°-183°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05051508 |
| 출처 데이터셋 | uspto-grants-1991_09 |
| ORD ID | ord-2edeca0174b046659926189dfbd51726 |
| 출처 메모 | uspto-grants-1991_09 |