HCID 19090869, 화합물 → HCID 19090866, 화합물

HRID 729166노트

반응식

HRID 729166 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20][PH:21](=[O:25])[O:22][CH2:23][CH3:24]>C(N(CC)CC)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]([P:21]([CH3:20])(=[O:25])[O:22][CH2:23][CH3:24])[OH:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 19090869HCID 19090869, 화합물HCID 178476777HCID 178476777, 화합물

생성물 1

HCID 19090866HCID 19090866, 화합물

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A solution of 1.46 g of 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-propionaldehyde, 0.54g of ethyl methylphosphinate and 0.695 ml of triethylamine is heated to 100° for 2 hours. The reaction mixture is cooled to room temperature and chromatographed on silica gel to give ethyl 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-1-hydroxypropyl(methyl)phosphinate.

후처리

  1. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-e206ba30c8294617aa33d9c1f9db5037
출처 데이터셋
uspto-grants-1991_09
특허 번호
US05051524

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