5-Chloro-1-benzofuran-2-carboxylic acid → 5-Chloro-1-benzofuran
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](C(O)=O)=[CH:7][C:6]=2[CH:13]=1>CN1CCCC1=O.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:13]=1참가 물질
4
반응 조건
- 온도
- 250 °C
실험 절차
To a solution of 5-chloro-1-benzofuran-2-carboxylic acid (0.2 g) in 1-methyl-2-pyrrolidinone (2 ml) was added copper granules (0.2 g). The reaction mixture was heated at 250° C. for 3.5 min in a microwave. The reaction vessel was cooled to room temperature and the mixture combined with four other similar mixtures and the combined mixtures partitioned between water and diethyl ether. The organic layer was washed with water and brine, dried (over magnesium sulphate) and concentrated under reduced pressure to give the title compound (0.65 g) as a yellow oil.
후처리
- temperatureThe reaction vessel was cooled to room temperature
- customthe combined mixtures partitioned between water and diethyl ether
- washThe organic layer was washed with water and brine
- dry with materialdried (over magnesium sulphate)
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a765f630bfcc4d368621ba25c966168e
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07084139B2
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