Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-Butyl hypochlorite → 2-Amino-5-chloro-4-fluorobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Amino-5-chloro-4-fluorobenzoic acid | HCID 21979255 | 111.2% |
반응 단계
To a solution of 4-fluoroanthranilic acid (0.882 g, 5.69 mmol) in methylene chloride (50 mL) and acetic acid (10 mL) is added tert-butyl hypochlorite (0.71 mL, 6.25 mmol) solution in dichloromethane (1 mL) dropwise over 1 minute. After 90 minutes, the reaction mixture is washed with water and brine. The organic layer is dried over MgSO4, filtered, and the filtrate concentrated to afford 5-chloro-4-fluoroanthranilic acid (1.20 g). MS CI: m/e 188 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582627B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-18e3885250ee4283ae0761a2468352ae |
| 출처 메모 | uspto-grants-2009_09 |