[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester → [1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

HRID 729432노트

반응식

HRID 729432 반응식
[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:16][CH2:15]2)[CH2:13][N:12](CC2C=CC=CC=2)[CH2:11]1)[CH3:9])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:24])[NH:7][CH:8]([CH:10]1[C:14]2([CH2:15][CH2:16]2)[CH2:13][NH:12][CH2:11]1)[CH3:9])([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 2

HCID 21041206[1-(5-Benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 21041207[1-(5-Azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of [1-(5-benzyl-5-azaspiro[2.4]hept-7-yl)ethyl]carbamic acid tert-butyl ester (Example A4a, 1.47 g) in methanol (30 mL) in a Parr shaker is treated with 10% palladium on carbon (0.5 g) and hydrogen introduced (50 psi) for 24 hours. The reaction mixture is filtered through celite, washed with methanol, and the combined filtrate concentrated in vacuo to afford the title compound. MS CI: m/z 241 (MH+).

후처리

  1. additionintroduced (50 psi) for 24 hours
  2. filtrationThe reaction mixture is filtered through celite
  3. washwashed with methanol
  4. concentrationthe combined filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-6a4262695dc942528ce938ff12436454
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582627B2

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