Ammonia → 5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

HRID 729452노트

반응식

HRID 729452 반응식
[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([O:19]C)=O)=[N:15][CH:16]=2)[CH2:7][CH2:6]1.[NH3:26]>CO>[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:12]=[CH:13][C:14]([C:17]([NH2:26])=[O:19])=[N:15][CH:16]=2)[CH2:7][CH2:6]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 57832729Methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate

생성물 1

HCID 690622895-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
55 °C

실험 절차

A methanol (30 mL) suspension of methyl 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]pyrazine-2-carboxylate from Step 3 (2.00 g, 4.87 mmol) in a sealed tube was saturated with ammonia gas at 0° C. The mixture was then heated in an oil bath at 55° C. for two days. The reaction mixture was cooled and evaporated. To the white solid residue was added ether followed by filtration to provide the title compound.

후처리

  1. temperatureThe reaction mixture was cooled
  2. customevaporated
  3. additionTo the white solid residue was added ether
  4. filtrationfollowed by filtration

출처 및 근거

ORD 기록
ord-88ac595096ee454cb0c4f32141dd1f42
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582633B2

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