Ammonia → HCID 45380634, 화합물
반응식
[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15](OC)=[O:16])=[N:13][CH:14]=2)[CH2:6]1.[NH3:24]>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15]([NH2:24])=[O:16])=[N:13][CH:14]=2)[CH2:6]1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.
후처리
- customthe methanol was evaporated
- additionfollowed by the addition of ether
- filtrationThe solid was filtered
출처 및 근거
- ORD 기록
- ord-7cd9bd263dd8487d8d6f087e9594ac51
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07582633B2
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