Boron tribromide → 4-Bromocatechol

HRID 729870

반응식

HRID 729870 반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:10]C)[C:5]([O:8]C)=[CH:6][CH:7]=1.B(Br)(Br)Br>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([OH:10])[C:5](=[CH:6][CH:7]=1)[OH:8]

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 76114Benzene, 4-bromo-1,2-dimethoxy-

생성물 1

HCID 284874-Bromocatechol수율 96.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

6.51 g (0.0300 mol) of 4-bromoveratrole is dissolved in 50 ml of dichloromethane. To this suspension is added 37.6 g (0.150 mol) of boron tribromide at 0° C. The mixture was stirred for 3 hours at room temperature. Solvents were removed under reduced pressure. The resulting brown oil was dissolved in ethyl acetate and filtered through a pad of silica gel. The filtrate was concentrated to afford 5.45 g of 4-bromo catechol as a light brown oil.

후처리

  1. customSolvents were removed under reduced pressure
  2. dissolutionThe resulting brown oil was dissolved in ethyl acetate
  3. filtrationfiltered through a pad of silica gel
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a93b7e37498b498d9f1c912a40155f65
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07582637B2

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